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Educational Resources
Guidelines
Resources
MTX Monitoring Tool
Expert Discussions
Clinical Articles

Educational Resources

Guidelines

Consensus Guidelines

<em>Consensus Guideline for Use of Glucarpidase in Patients with High‐Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.</em>

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Highlights - Consensus Guidelines

Highlighted excerpts from the <em>Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.</em>

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Glucarpidase Treatment Algorithm

Download and print for your practice: Treatment algorithm based on the Consensus Guidelines.

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Stocking Guidelines

Review the stocking guidelines established by an international expert panel.

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NCCN Guidelines

Review the National Comprehensive Cancer Network Guidelines for treating various cancers.

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Resources

Early Warning Signs

Download this resource to help you identify the early warning signs for methotrexate toxicity.

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Voraxaze® 5-Minute Educational Video

Watch and learn about the importance of identifying HDMTX toxicity and when to use Voraxaze<sup>&reg;</sup>.

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MTX Monitoring Tool

Methotrexate Monitoring Tool

Visit MTXPK.org to see if your patient is clearing MTX as expected. This tool was independently developed by Dr. Laura Ramsey of Cincinnati Children&rsquo;s Medical Center and lead author of the Consensus Guidelines<sup>5</sup> and provides:<br /> &nbsp; <ul> <li>A free, open-access clinical decision-making tool for monitoring plasma MTX elimination in both adult and pediatric patients</li> <li>No log in required</li> <li>No patient data stored on the website (but can be stored to local computer and browser)</li> <li>Visual display of data shows expected and actual MTX elimination curves along with serum creatinine trend and predicted time to reach discharge threshold levels</li> <li>Patient report can be downloaded and saved as PDFs or printed</li> </ul>

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MTXPK Tutorial Video

MTXPK Tutorial Video

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Expert Discussions

OncLive® Webinar

Watch leading experts discuss the current landscape of high-dose methotrexate toxicity and treatment options to improve patient outcomes.

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<em>The ASCO® Post</em> CME

Review a roundtable discussion between 3 experts about how to identify patients treated with HDMTX who are at risk for developing AKI, the clinical implications of guidelines, and strategies to integrate guidelines into practice.

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Consensus Guideline Expert Interview

Watch and listen to experts discuss important information about guidelines for managing patients with delayed methotrexate elimination due to renal impairment.

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JADPRO CE

Review the management of delayed MTX elimination due to AKI according to published clinical guidelines using two certified case-based activities of HDMTX toxicity created for oncology advanced practitioners.<br /> &nbsp;

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Clinical Articles

<em>Length of stay, mortality, and readmissions among Medicare cancer patients treated with glucarpidase and conventional care: a retrospective study.

Examine hospital length of stay, mortality, and readmission rates for Medicare cancer patients with delayed clearance of MTX treated with glucarpidase.

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<em>MTXPK.org</em>

A Clinical Decision Support Tool Evaluating High‐Dose Methotrexate Pharmacokinetics to Inform Post‐Infusion Care and Use of Glucarpidase.

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