Expert Guidelines

Consensus Guidelines Strongly Recommend: Act Early With Voraxaze®1

Beyond 48 to 60 hours, life-threatening toxicities and even death may not be preventable. Early and rapid reduction of methotrexate (MTX) concentrations can lower the risk of irreversible damage.1

Consensus guidelines for use recommend administration of Voraxaze® at 48 hours following initiation of high-dose methotrexate (HDMTX) therapy when MTX concentrations are above 5 μM (2.27 μg/mL) and the serum creatinine is elevated relative to the baseline measurement.1

Download the Algorithm Review Guideline Highlights

Voraxaze® Is Included in Multiple NCCN Guidelines2

Over the past 25 years, the National Comprehensive Cancer Network (NCCN) has developed guidelines in oncology to document evidence-based, consensus-driven management to ensure that all patients receive treatment that is most likely to lead to optimal outcomes.

Voraxaze® is included in the following guidelines:

  • Central nervous system cancers
  • Acute lymphoblastic leukemia
  • Pediatric acute lymphoblastic leukemia
  • B-cell lymphomas
  • T-cell lymphomas
  • Primary cutaneous lymphomas
<p>Early intervention with Voraxaze<sup>&reg;</sup>, a recombinant bacterial enzyme that provides an alternative route for methotrexate clearance, has shown efficacy in rapidly reducing plasma concentrations of methotrexate and preventing severe toxicity.</p>
NCCN Guidelines for CNS Cancers2

Guidelines Advise Having 5 Vials of Voraxaze® Readily Available3

  • Expert Consensus Guidelines published in 2018 recommend that all hospitals that provide emergency care should stock 5 vials of Voraxaze®3
  • The Institute for Safe Medication Practices (ISMP) recommends that all appropriate antidotes should be readily available4
  • Standardized protocols and/or a coupled order should be set in place that permit the emergency administration of all appropriate antidotes used in the facility4

Stock Voraxaze® According to Guidelines

Not every patient requires Voraxaze®, but having it on hand can help you be prepared in an emergency.

Order Voraxaze<sup>®</sup> Today