Consensus guidelines for use recommend administration of Voraxaze® (glucarpidase) at 48 hours following initiation of high-dose methotrexate (HDMTX) therapy when MTX concentrations are above 5 μM (2.27 μg/mL) and the serum creatinine is elevated relative to the baseline measurement.1
Beyond 48 to 60 hours, life-threatening toxicities and even death may not be preventable. Early and rapid reduction of methotrexate (MTX) concentrations can lower the risk of irreversible damage.1
*For MTX doses of 1-8 g/m2 over 24 hours, if MTX concentration is >120 μM or CrCl is greater than 1.5x baseline, continue supportive care and check MTX concentration at 36 hours1. CrCl, creatinine clearance.
Not every patient requires Voraxaze, but having it on hand can help you be prepared in an emergency.