Meet Matthew, an osteosarcoma survivor, and learn how Voraxaze was a pivotal part of his successful fight against osteosarcoma. ➔

Meet Matthew, an osteosarcoma survivor, who received Voraxaze. ➔

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Prescribing Information
Important Safety Information
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ORDER AND 
REIMBURSEMENT 
FOR VORAXAZE

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How do I order Voraxaze® (glucarpidase)?

Emergency, Expedited, Urgent Orders – Call ASD at 1-855-786-7292

To order Voraxaze now and if you have a patient in need, call 1-855-786-7292 to place your order through our Specialty Distributor Partner, ASD Healthcare. ASD has an on-call team available and can process Voraxaze orders 24/7/365. ASD can process orders for expedited or next-day delivery – same-day emergency delivery is also available; delivery times vary by geography and time of order.

Stocking, Non-Urgent Orders

Voraxaze can be ordered through the following drop-ship partners, Monday-Thursday, until 3PM Eastern Time, for next-day delivery (same-day and expedited delivery is not available through these partners):

  • AmerisourceBergen
  • Cardinal Health
  • McKesson Plasma & Biologics

You may also email voraxaze@btgsp.com for questions and support.

Expert Consensus Guidelines for Stocking Antidotes in Hospitals That Provide Emergency Care

All hospitals that provide emergency care should stock 5 vials of Voraxaze. 

View Guidelines

Voraxaze Reimbursement

Please call us at 1-844-293-0007 to reach a reimbursement support specialist or email us at BTG@thepinnaclehealthgroup.com and your inquiry will be routed to our reimbursement support team to assist you with your needs and any other questions you may have.

Depending on your patient, when using Voraxaze, your institution may be eligible for an Outlier Payment. Please see below information for further details on Coding and Outlier Payments.

Download Coding Guide
Hospital Outlier Payment Backgrounder

Learn how to maximize inpatient hospital reimbursements for your institution through this enduring CE-accredited webinar presented at the Advanced Topics for Oncology Pharmacy Professionals (ATOPP) Summit in 2024.

Unlocking Inpatient Hospital Reimbursements: Best Practices for Oncology Institutions to Optimize Revenue Streams and Patient Care
Unlocking Inpatient Hospital Reimbursements
References
1.

Dart RC, Goldfrank LR, Erstad BL, et al. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med. 2018;71(3):314-325.

To Order Voraxaze® Now, Call 1-855-786-7292
Indication and Important Safety Information
Indication and Limitations of Use
  • Voraxaze® is a carboxypeptidase indicated to reduce toxic plasma methotrexate concentration (greater than 1 micromole per liter) in adult and pediatric patients with delayed methotrexate clearance (plasma methotrexate concentrations greater than 2 standard deviations of the mean methotrexate excretion curve specific for the dose of methotrexate administered) due to impaired renal function
  • Limitations of Use: Voraxaze® is not recommended for use in patients who exhibit the expected clearance and expected plasma methotrexate concentration. Reducing plasma methotrexate concentration in these patients may result in subtherapeutic exposure to methotrexate
Important Safety Information
WARNINGS AND PRECAUTIONS

Serious Hypersensitivity Reactions

  • Serious hypersensitivity reactions, including anaphylactic reactions, may occur. Serious hypersensitivity reactions occurred in less than 1% of patients

Monitoring Methotrexate Concentration/Interference with Assay

  • Methotrexate concentrations within 48 hours following Voraxaze® administration can only be reliably measured by a chromatographic method due to interference from metabolites. Measurement of methotrexate concentrations within 48 hours of Voraxaze® administration using immunoassays results in an overestimation of the methotrexate concentration

ADVERSE REACTIONS

  • In clinical trials, the most common related adverse events (occurring in >1% of patients) were paresthesia, flushing, nausea and/or vomiting, hypotension and headache

DRUG INTERACTIONS

  • Voraxaze® can decrease leucovorin concentration, which may decrease the effect of leucovorin rescue unless leucovorin is dosed as recommended, and may also reduce the concentrations other folate analogs or folate analog metabolic inhibitors

Please see full Prescribing Information.