Meet Matthew, an osteosarcoma survivor, and learn how Voraxaze was a pivotal part of his successful fight against osteosarcoma. ➔

Meet Matthew, an osteosarcoma survivor, who received Voraxaze. ➔

This site is intended for US Healthcare Professionals Only

USA Flag
Prescribing Information
Important Safety Information
Placeholder

Sign Up

rectangle-white-left-angle

Get More Information About Voraxaze®(glucarpidase)

To report a suspected adverse event associated with Voraxaze, please email vigilance@btgsp.com.

For general questions about Voraxaze or SERB Pharmaceuticals, please click here to contact us.

Please complete the following to speak with a representative and/or receive information and updates about Voraxaze. All fields are required.

For medical information inquiries on Voraxaze, please contact:

Specialty Solutions Center®
1-844-293-0007
24 hours/day, 7 days/week

Or you can call our Medical Information Call Center directly at 1-877-377-3784 or email btgpharmamedicalinfo@btgsp.com.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is for US residents only. The information on this website should not take the place of talking with a physician or healthcare professional.

To Order Voraxaze® Now, Call 1-855-786-7292
Indication and Important Safety Information
Indication and Limitations of Use
  • Voraxaze® is a carboxypeptidase indicated to reduce toxic plasma methotrexate concentration (greater than 1 micromole per liter) in adult and pediatric patients with delayed methotrexate clearance (plasma methotrexate concentrations greater than 2 standard deviations of the mean methotrexate excretion curve specific for the dose of methotrexate administered) due to impaired renal function
  • Limitations of Use: Voraxaze® is not recommended for use in patients who exhibit the expected clearance and expected plasma methotrexate concentration. Reducing plasma methotrexate concentration in these patients may result in subtherapeutic exposure to methotrexate
Important Safety Information
WARNINGS AND PRECAUTIONS

Serious Hypersensitivity Reactions

  • Serious hypersensitivity reactions, including anaphylactic reactions, may occur. Serious hypersensitivity reactions occurred in less than 1% of patients

Monitoring Methotrexate Concentration/Interference with Assay

  • Methotrexate concentrations within 48 hours following Voraxaze® administration can only be reliably measured by a chromatographic method due to interference from metabolites. Measurement of methotrexate concentrations within 48 hours of Voraxaze® administration using immunoassays results in an overestimation of the methotrexate concentration

ADVERSE REACTIONS

  • In clinical trials, the most common related adverse events (occurring in >1% of patients) were paresthesia, flushing, nausea and/or vomiting, hypotension and headache

DRUG INTERACTIONS

  • Voraxaze® can decrease leucovorin concentration, which may decrease the effect of leucovorin rescue unless leucovorin is dosed as recommended, and may also reduce the concentrations other folate analogs or folate analog metabolic inhibitors

Please see full Prescribing Information.