SAFETY

Most Common Adverse Reactions With Voraxaze®(glucarpidase) Treatment1
Adverse reaction |
N=290, n (%) |
---|---|
Paresthesia |
7 (2%) |
Flushing✝︎ |
5 (2%) |
Nausea/Vomiting |
5 (2%) |
Headache |
2 (1%) |
Hypotension |
2 (1%) |
*Excluding hematologic, hepatic, or renal adverse reactions. ✝︎This adverse reaction includes the following terms: flushing, feeling hot, burning sensation.
- Adverse reaction severity was rated as Grade 1 or Grade 2 for all events, except for 1 patient who reported Grade 3 flushing.1
- Adverse reactions related to toxic methotrexate (MTX) levels due to prolonged MTX clearance included myelosuppression, mucositis, acute hepatitis, and renal dysfunction and failure.1